Metabolic Syndrome

World’s biggest killer: Hyperinsulinaemia

In an excellent report about hyperinsulinaemia/Insulin resistance by Michael Joseph MSc the following valuable information become available;

Full article:

Hyperinsulinaemia refers to when the body is producing to much insulin to keep high blood sugar levels in check. Without adequate intervention chronic hyperinsulinaemia can lead to type 2 Diabetes.

But hyperinsulinaemia is associated with the metabolic syndrome and is harmful independent of Diabetes.

What causes insulin resistance, hyperinsulinaemia and metabolic syndrome; there are several factors but most of all our modern diet with refines sugars and ultraprocessed foods with too much carbohydrates.

Link between Hyperinsulinaemia and Chronic disease.

Alzheimer: Hyperinsulinaemia has a robust association with a higher risk of Alzheimer’s disease. Ref: 150980

Cancer: Individuals with high levels of insulin have a 62% higher risk of cancer mortality. Chronic Hyperinsulinaemia may raise cancer risk by increasing the bioligical activity of IGF-1 which can help tumor growth. Insulin can also directly influence tumor growth.

Cardiovascular disease:

Hyperinsulinaemia stimulates production of proinflammatory cytokines in vascular systems and endothelial cells promoting premature atherosclerosis.

Chronic kidney disease:

Hyperinsulinaemia can lead to CKD through oxidative stress, stimulating growth factors and downregulating renal receptors.


Key Point: Hyperinsulinaemia appears to play a pivotal role in the pathology of major chronic diseases. 

How can we reverse insulin resistance?

Low carbohydrate diets.


Good sleep.



Metabolic Syndrome

American adult population just getting fatter and fatter.

In an article in the new York time By MATT RICHTEL and ANDREW JACOBSMARCH dated 23 March 2018 American adults continue to put on the pounds. New data shows that nearly 40 percent of them were obese in 2015 and 2016, a sharp increase from a decade earlier, federal health officials reported Friday.
The prevalence of severe obesity in American adults is also rising, heightening their risks of developing heart disease, diabetes and various cancers. According to the latest data, published Friday in JAMA, 7.7 percent of American adults were severely obese in the same period.
The data — gathered in a large-scale federal survey that is considered the gold standard for health data — measured trends in obesity from 2015 and 2016 back to 2007 and 2008, when 5.7 percent of American adults were severely obese and 33.7 percent were obese. The survey counted people with a body mass index of 30 or more as obese, and those with a B.M.I. of 40 or more as severely obese.
Public health experts said that they were alarmed by the continuing rise in obesity among adults and by the fact that efforts to educate people about the health risks of a poor diet do not seem to be working.
“Most people know that being overweight or obese is unhealthy, and if you eat too much that contributes to being overweight,” said Dr. James Krieger, clinical professor of medicine at the University of Washington and executive director of Healthy Food America, an advocacy group. “But just telling people there’s a problem doesn’t solve it.”

The latest data from the National Health and Nutrition Examination Survey comes at a time when the food industry is pushing back against stronger public health measures aimed at combating obesity.
In recent NAFTA negotiations, the Trump administration has proposed rules favored by major food companies that would limit the ability of the United States, Mexico and Canada to require prominent labels on packaged foods warning about the health risks of foods high in sugar and fat.
While the latest survey data doesn’t explain why Americans continue to get heavier, nutritionists and other experts cite lifestyle, genetics, and, most importantly, a poor diet as factors. Fast food sales in the United States rose 22.7 percent from 2012 to 2017, according to Euromonitor, while packaged food sales rose 8.8 percent.