Metabolic Syndrome

World’s biggest killer: Hyperinsulinaemia

In an excellent report about hyperinsulinaemia/Insulin resistance by Michael Joseph MSc the following valuable information become available;

Full article: http://nutritionadvance.com/hyperinsulinemia.insulin.resistance.

Hyperinsulinaemia refers to when the body is producing to much insulin to keep high blood sugar levels in check. Without adequate intervention chronic hyperinsulinaemia can lead to type 2 Diabetes.

But hyperinsulinaemia is associated with the metabolic syndrome and is harmful independent of Diabetes.

What causes insulin resistance, hyperinsulinaemia and metabolic syndrome; there are several factors but most of all our modern diet with refines sugars and ultraprocessed foods with too much carbohydrates.

Link between Hyperinsulinaemia and Chronic disease.

Alzheimer: Hyperinsulinaemia has a robust association with a higher risk of Alzheimer’s disease. Ref: http://content.iospress.com/articles/joural-of-alzheimers-disease/jad 150980

Cancer: Individuals with high levels of insulin have a 62% higher risk of cancer mortality. Chronic Hyperinsulinaemia may raise cancer risk by increasing the bioligical activity of IGF-1 which can help tumor growth. Insulin can also directly influence tumor growth.

Cardiovascular disease:

Hyperinsulinaemia stimulates production of proinflammatory cytokines in vascular systems and endothelial cells promoting premature atherosclerosis.

Chronic kidney disease:

Hyperinsulinaemia can lead to CKD through oxidative stress, stimulating growth factors and downregulating renal receptors.

 

Key Point: Hyperinsulinaemia appears to play a pivotal role in the pathology of major chronic diseases. 

How can we reverse insulin resistance?

Low carbohydrate diets.

Exercise.

Good sleep.

 

 

Metabolic Syndrome

NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

“Non Alcoholic Fatty Liver Disease is one of the common complications of obese people with metabolic syndrome. It is very common and the incidence is rising with the incidence of obesity and metabolic syndrome. It is dangerous and can lead to chirrosis and liver failure. It will soon be the commonest cause of liver transplanation”.

Fatty liver is a condition in which the cells of the liver accumulate abnormally increased amounts of fat. Although excessive consumption of alcohol is a very common cause of fatty liver (alcoholic fatty liver), there is another form of fatty liver, termed nonalcoholic fatty liver disease (nonalcoholic fatty liver disease), in which alcohol has been excluded as a cause. In nonalcoholic fatty liver disease, other recognized causes of fatty liver that are less common causes than alcohol also are excluded.

Nonalcoholic fatty liver disease is a manifestation of an abnormality of metabolism within the liver. The liver is an important organ in the metabolism (handling) of fat. The liver makes and exports fat to other parts of the body. It also removes fat from the blood that has been released by other tissues in the body, for example, by fat cells, or absorbed from the food we eat. In nonalcoholic fatty liver disease, the handling of fat by liver cells is disturbed. Increased amounts of fat are removed from the blood and/or are produced by liver cells, and not enough is disposed of or exported by the cells. As a result, fat accumulates in the liver.

Nonalcoholic fatty liver disease is classified as either fatty liver (sometimes referred to as isolated fatty liver or IFL) or steatohepatitis (NASH). In both isolated fatty liver and NASH there is an abnormal amount of fat in the liver cells, but, in addition, in NASH there is inflammation within the liver, and, as a result, the liver cells are damaged, they die, and are replaced by scar tissue.

 

Nonalcoholic fatty liver disease is important for several reasons. First, it is a common disease, and is increasing in prevalence. Second, NASH is an important cause of serious liver disease, leading to cirrhosis and the complications of cirrhosis–liver failure, gastrointestinal bleeding, and liver cancer. Third, nonalcoholic fatty liver disease is associated with other very common and serious non-liver diseases, perhaps the most important being metabolic syndrome with the associated cardiovascular disease that leads to heart attacks and strokes. Fatty liver probably is not the cause of these other diseases, but is a manifestation of metabolic syndrome that the diseases share. Fatty liver, therefore, is a clue to the presence metabolic syndrome and the  serious complications of the disease which need to be addressed.

Metabolic Syndrome, Uncategorized

What are my chances to have metabolic syndrome????

If you have the following:

  1. BMI over 32. (BMI=Weight in kg/square of your length in meters).
  2. Abdominal circumference of over 95cm. for men and 85 cm. for women.
  3. Blood pressure of over 130/90 or on hypertension treatment.
  4. Fasting Blood glucose of over 5,8 mmol/Liter.
  5. Inactive with exercise intolerance.

If you have all 5 your chances are over 90% of having metabolic syndrome.

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