In an excellent report about hyperinsulinaemia/Insulin resistance by Michael Joseph MSc the following valuable information become available;
Hyperinsulinaemia refers to when the body is producing to much insulin to keep high blood sugar levels in check. Without adequate intervention chronic hyperinsulinaemia can lead to type 2 Diabetes.
But hyperinsulinaemia is associated with the metabolic syndrome and is harmful independent of Diabetes.
What causes insulin resistance, hyperinsulinaemia and metabolic syndrome; there are several factors but most of all our modern diet with refines sugars and ultraprocessed foods with too much carbohydrates.
Link between Hyperinsulinaemia and Chronic disease.
Alzheimer: Hyperinsulinaemia has a robust association with a higher risk of Alzheimer’s disease. Ref: http://content.iospress.com/articles/joural-of-alzheimers-disease/jad 150980
Cancer: Individuals with high levels of insulin have a 62% higher risk of cancer mortality. Chronic Hyperinsulinaemia may raise cancer risk by increasing the bioligical activity of IGF-1 which can help tumor growth. Insulin can also directly influence tumor growth.
Hyperinsulinaemia stimulates production of proinflammatory cytokines in vascular systems and endothelial cells promoting premature atherosclerosis.
Chronic kidney disease:
Hyperinsulinaemia can lead to CKD through oxidative stress, stimulating growth factors and downregulating renal receptors.
Key Point: Hyperinsulinaemia appears to play a pivotal role in the pathology of major chronic diseases.
How can we reverse insulin resistance?
Low carbohydrate diets.