Metabolic Syndrome

Low Carbohydrate High Fat Diets

Numerous studies indicate that a very low carbohydrate diet (below 50 grams carbohydrates per day) is exceptional beneficial for Diabetes Type 2 patients as well as obese patients.

 

Since the carbohydrate content of the diet is significantly reduced, the relative proportion of energy derived from protein or fat will increase. In practice however the LCHF diet typical produce a reduction in hunger. The result is that a person on LCHF diet usually experience a decrease in caloric consumption, sometimes significantly.

 

 

Very LCHF (ketogenic) diets may induce ketosis in some people. Though individual responses vary, ketosis usually occurs in people who restrict their carbohydrate intake to below 20–50 g/day with exercise and protein restriction.

 

What is a LCHF diet: food with a focus on eating unprocessed food, consisting primarily of leafy vegetables, nuts , eggs, fish, unprocessed animal meats, dairy products and plant fats e.g. avocados, coconuts and olives.

 

 

Several studies show that LCHF diets are more effective that other diets in weight loss. Some studies emphasize the relative ease of adopting a LCHF diet and losing weight.

How does LCHF diet brings about weight loss?

Increased protein of LCHF  cause a lower energy intake without hunger

 

1) Increase  protein intake supress satiety.

2) Ketogenic LCHF diets cause low grade nausea in most people that suppresses appetite.

(3) Carbohydrates in food causes insulin to spike and that causes hunger. This does not happen in LCHF diets.

 

LCHF diets have a further advantage that could not be explained by less calories intake. Most people never felt that they eat that amount of less food for the big weight loss they experienced.

 

We do know that LCHF diets increase reliance on fat oxidation for energy production, especially during exercise,as shown by increased blood ketone concentrations. This lead to lipolysis with breakdown of a patients fat stores.

 

 

 

 

LCHF diets and Type 2 Diabetes Mellitus (T2DM)

 

 

 

T2DM is primarily a condition of IR, with persistent hyperglycaemia as a result of excessive hepatic glucose production.Of all the macronutrients, carbohydrates cause the greatest and most prolonged increases in blood glucose and insulin concentrations. It is therefore no surprise that prior to the discovery of insulin, carbohydrate restriction, often associated with fasting or even starvation, was the eating plan prescribed for all diabetic patients regardless of type (1 or 2). Today, LCHF diets are again a potential first-line treatment for T2DM.

Numerous studies of which most are quoted in this website prove that a LCHF diet decreases HbA1c levels more than any other diet. HbA1C is an indication of a person’s blood glucose value over the last 3 months. Numerous examples exist where people could lower or stop their antidiabetic drugs after introducing a LCHF diet.

 

LCHF diets and cardiovascular risk factors

Evidence from numerous randomized control studies indicate that LCHF diets consistently produce more favourable changes in many measures of cardiovascular risk than do LFHC diets. This applies especially in persons with insulin resistance, type 2 Diabetes, atherosclerotic dyslipaedemia and Non Alcoholic fatty liver disease.

Examination of blood lipid concentrations in RCTs reveals that LCHF diets have a potent effect in lowering blood TG concentrations,to a significantly greater degree than do LFHC diets.Blood ApoB concentrations—an indirect measure of lipoprotein particle numbers and also a risk predictor for coronary artery disease—also decrease more on LCHF than on the LFHC diet.

Furthermore, of all dietary interventions, none increase HDL-C concentrations as effectively as do LCHF diets.

 

 

NAFLD, AD and LCHF

NAFDL= Non Alcoholic Fatty Liver disease

AD=Atherogenic Dyslipaedemia.

 

Cardiovascular disease is the leading cause of death in NAFLD,a condition causing elevated TG and low HDL-C concentrations with overproduction of very-low density lipoproteins and impaired clearance of TG-rich lipoproteins. Hepatic IR is also increased in persons with fatty liveras shown by inadequate suppression of hepatic glucose production by insulin in NAFLD

Since NAFLD is caused by excessive carbohydrate,the finding that a carbohydrate-restricted LCHF diet can reverse AD  is more readily explained. The LCHF diet reverses the NAFLD and hence the AD that it causes.

 

 

Metabolic Syndrome

World’s biggest killer: Hyperinsulinaemia

In an excellent report about hyperinsulinaemia/Insulin resistance by Michael Joseph MSc the following valuable information become available;

Full article: http://nutritionadvance.com/hyperinsulinemia.insulin.resistance.

Hyperinsulinaemia refers to when the body is producing to much insulin to keep high blood sugar levels in check. Without adequate intervention chronic hyperinsulinaemia can lead to type 2 Diabetes.

But hyperinsulinaemia is associated with the metabolic syndrome and is harmful independent of Diabetes.

What causes insulin resistance, hyperinsulinaemia and metabolic syndrome; there are several factors but most of all our modern diet with refines sugars and ultraprocessed foods with too much carbohydrates.

Link between Hyperinsulinaemia and Chronic disease.

Alzheimer: Hyperinsulinaemia has a robust association with a higher risk of Alzheimer’s disease. Ref: http://content.iospress.com/articles/joural-of-alzheimers-disease/jad 150980

Cancer: Individuals with high levels of insulin have a 62% higher risk of cancer mortality. Chronic Hyperinsulinaemia may raise cancer risk by increasing the bioligical activity of IGF-1 which can help tumor growth. Insulin can also directly influence tumor growth.

Cardiovascular disease:

Hyperinsulinaemia stimulates production of proinflammatory cytokines in vascular systems and endothelial cells promoting premature atherosclerosis.

Chronic kidney disease:

Hyperinsulinaemia can lead to CKD through oxidative stress, stimulating growth factors and downregulating renal receptors.

 

Key Point: Hyperinsulinaemia appears to play a pivotal role in the pathology of major chronic diseases. 

How can we reverse insulin resistance?

Low carbohydrate diets.

Exercise.

Good sleep.

 

 

Metabolic Syndrome

American adult population just getting fatter and fatter.

In an article in the new York time By MATT RICHTEL and ANDREW JACOBSMARCH dated 23 March 2018 American adults continue to put on the pounds. New data shows that nearly 40 percent of them were obese in 2015 and 2016, a sharp increase from a decade earlier, federal health officials reported Friday.
The prevalence of severe obesity in American adults is also rising, heightening their risks of developing heart disease, diabetes and various cancers. According to the latest data, published Friday in JAMA, 7.7 percent of American adults were severely obese in the same period.
The data — gathered in a large-scale federal survey that is considered the gold standard for health data — measured trends in obesity from 2015 and 2016 back to 2007 and 2008, when 5.7 percent of American adults were severely obese and 33.7 percent were obese. The survey counted people with a body mass index of 30 or more as obese, and those with a B.M.I. of 40 or more as severely obese.
Public health experts said that they were alarmed by the continuing rise in obesity among adults and by the fact that efforts to educate people about the health risks of a poor diet do not seem to be working.
“Most people know that being overweight or obese is unhealthy, and if you eat too much that contributes to being overweight,” said Dr. James Krieger, clinical professor of medicine at the University of Washington and executive director of Healthy Food America, an advocacy group. “But just telling people there’s a problem doesn’t solve it.”

The latest data from the National Health and Nutrition Examination Survey comes at a time when the food industry is pushing back against stronger public health measures aimed at combating obesity.
In recent NAFTA negotiations, the Trump administration has proposed rules favored by major food companies that would limit the ability of the United States, Mexico and Canada to require prominent labels on packaged foods warning about the health risks of foods high in sugar and fat.
While the latest survey data doesn’t explain why Americans continue to get heavier, nutritionists and other experts cite lifestyle, genetics, and, most importantly, a poor diet as factors. Fast food sales in the United States rose 22.7 percent from 2012 to 2017, according to Euromonitor, while packaged food sales rose 8.8 percent.

 

 

Metabolic Syndrome

NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

“Non Alcoholic Fatty Liver Disease is one of the common complications of obese people with metabolic syndrome. It is very common and the incidence is rising with the incidence of obesity and metabolic syndrome. It is dangerous and can lead to chirrosis and liver failure. It will soon be the commonest cause of liver transplanation”.

Fatty liver is a condition in which the cells of the liver accumulate abnormally increased amounts of fat. Although excessive consumption of alcohol is a very common cause of fatty liver (alcoholic fatty liver), there is another form of fatty liver, termed nonalcoholic fatty liver disease (nonalcoholic fatty liver disease), in which alcohol has been excluded as a cause. In nonalcoholic fatty liver disease, other recognized causes of fatty liver that are less common causes than alcohol also are excluded.

Nonalcoholic fatty liver disease is a manifestation of an abnormality of metabolism within the liver. The liver is an important organ in the metabolism (handling) of fat. The liver makes and exports fat to other parts of the body. It also removes fat from the blood that has been released by other tissues in the body, for example, by fat cells, or absorbed from the food we eat. In nonalcoholic fatty liver disease, the handling of fat by liver cells is disturbed. Increased amounts of fat are removed from the blood and/or are produced by liver cells, and not enough is disposed of or exported by the cells. As a result, fat accumulates in the liver.

Nonalcoholic fatty liver disease is classified as either fatty liver (sometimes referred to as isolated fatty liver or IFL) or steatohepatitis (NASH). In both isolated fatty liver and NASH there is an abnormal amount of fat in the liver cells, but, in addition, in NASH there is inflammation within the liver, and, as a result, the liver cells are damaged, they die, and are replaced by scar tissue.

 

Nonalcoholic fatty liver disease is important for several reasons. First, it is a common disease, and is increasing in prevalence. Second, NASH is an important cause of serious liver disease, leading to cirrhosis and the complications of cirrhosis–liver failure, gastrointestinal bleeding, and liver cancer. Third, nonalcoholic fatty liver disease is associated with other very common and serious non-liver diseases, perhaps the most important being metabolic syndrome with the associated cardiovascular disease that leads to heart attacks and strokes. Fatty liver probably is not the cause of these other diseases, but is a manifestation of metabolic syndrome that the diseases share. Fatty liver, therefore, is a clue to the presence metabolic syndrome and the  serious complications of the disease which need to be addressed.

Diabetes Mellitus type 2, Metabolic Syndrome

Diabetes Type 2 with Metabolic Syndrome: case study.


Patient is a 65 year old pathologist. Was reasonably active with cycling and horseriding. He was overweight and enjoyed a social life with a daily glass of wine and occasional beers over weekends. He experienced exercise intolerance and was on treatment for cholesterol, hypertension, gout and an arythmia that kept him awake at night. He also took one Ecotrin daily.

On 27 July he tested a continous glucose monitor for Metronic just to find out that he has an average blood glucose value of 10 mmol/ml. He was surprised because at the end of 2016 he was screened for an insurance policy and nothing was wrong.

For obvious reasons he started to study Diabetes and Metabolic Syndrome and came to the conclusion that there is no quick cure for this disease and that if he want to survive this challenge he must change his ways. He also realized that he was treating the symptoms of Metabolic Syndrome – a common mistake. (Hypertension, gout, high cholesterol and arythmia). He learned for the first time in his life that if he could control metabolic syndrome, he may not need al these chronic medications.

At this stage his clinical profile was as follow:

Weight: 117 kg.

BMI: 34,94

Fasting Blood Sugar: 9,8

HDL-cholesterol: 1,4 mmol/L

LDL-cholesterol: 3,2 mmol/L

C-reactive protein: 3,9 mg/L

HbA1c: 7,8%

Exercise History: 30 minutes cycling per week.

On 17 January 2018 after all the principles proposed by newCare innovation were applied, the following clinical criteria were observed:

Weight: 95 kg.

BMI: 28,37

Fasting Blood Sugar: 5,2

HDL-cholesterol: 1,9mmol/L

LDL-cholesterol: 2,6mmol/L

C-reactive protein: 1,6mg/L

HbA1c: 5,8%

Exercise History: Minimum of 6 hours running and cycling per week.

His excercise intolerance and activity level was exceptional and on Friday 9 March 2018 he ran 10,3 km in 1,05 hour. (Something that he last did in the army in 1971).

If you think this is exceptional you are wrong. In the most recent literature all over the world this is happening more and more. Old obese people are reviving under good advice and after aquiring the support, knowledge and skills from professional people about Metabolic Syndrome. Worst of all is that the knowledge of general practitioners and specialist about the effect and treatment of metabolic syndrome is currently limited.

He stopped all medical treatment for cholesterol, high blood pressure, arythmia and gout. He currently is just using one Ecotrin and 1 gram of Metformin per day.

When this photo was taken 3 March 2018 his weight was 86 kg. Just after the photo was taken he climbed a spoiled black arabian stallion who injured him 2 years ago; just for the challenge. It was succesful.